The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …

Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase
VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell …

Both vascular endothelial growth factor receptors (VEGFR) and integrins are major
regulators of VEGF-induced angiogenesis. Previous work has shown that β3 integrin can …

The biological functions of VEGF-B in cancer progression remain poorly understood. Here,
we report that VEGF-B promotes cancer metastasis through the remodeling of tumor …

In this review we summarize the current understanding of signal transduction downstream of
vascular endothelial growth factor A (VEGFA) and its receptor VEGFR 2, and the relationship …

Cell organization is largely orchestrated by extracellular gradients of morphogenetic
proteins. VEGF, an essential factor for capillary formation, is stored in the extracellular …

The known responses of vascular endothelial growth factor (VEGF) are mediated through
VEGF receptor-2 (VEGFR-2/KDR) in endothelial cells. However, it is unknown whether …

Background VEGF proteolysis by plasmin or matrix metalloproteinases (MMPs) is believed
to play an important role in regulating vascular patterning in vivo by releasing VEGF from the …

Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene
delivery failed to show efficacy. Major challenges include the need to precisely control in …

Neuropilin (NRP) 1, previously identified as a neuronal receptor that mediates repulsive
growth cone guidance, has been shown recently to function also in endothelial cells as an …