Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

It is widely accepted that communication between the nervous and immune systems is
involved in the development of chronic pain. At each level of the nervous system, immune …

Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …

Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such
neuropathic pain conditions, sensory processing in the affected body region becomes …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

Recent evidence implicates an adaptive immune response in the central nervous system
(CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters …

Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …

Chronic pain is a long-standing unpleasant sensory and emotional feeling that has a
tremendous impact on the physiological functions of the body, manifesting itself as a …