Insulin resistance—an impairment in the ability of insulin to appropriately regulate glucose
and lipid metabolism—is an early and key defect associated with weight gain (obesity), type …

It has been hypothesized that insulin resistance is mediated by a deficiency of mitochondria
in skeletal muscle. In keeping with this hypothesis, high-fat diets that cause insulin …

Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …

The prevalence of type 2 diabetes mellitus (DM2) is increasing precipitously as a
consequence of the aging population and obesity epidemic. Type 2 diabetes mellitus is …

Based on evidence that patients with type 2 diabetes (T2DM), obese insulin-resistant
individuals, and lean insulin-resistant offspring of parents with T2DM have∼ 30% less …

Background Insulin resistance appears to be the best predictor of the development of
diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is …

The precise cause of insulin resistance and type 2 diabetes is unknown. However, there is a
strong association between insulin resistance and lipid accumulation—and, in particular …

Patients with type 2 diabetes, insulin-resistant obese individuals, and insulin-resistant
offspring of patients with diabetes have≈ 30% less mitochondria in their skeletal muscles …

The inability of insulin to stimulate glucose metabolism in skeletal muscle is a classic
characteristic of type 2 diabetes, but this insulin resistance entails altered patterns of lipid …

There is now much interest in the mechanisms by which altered lipid metabolism might
contribute to insulin resistance as is found in Syndrome X or in Type II diabetes. This review …