Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders

M Xiao, G Hu - CNS neuroscience & therapeutics, 2014 - Wiley Online Library
Summary Aquaporin 4 (AQP 4) is the main water channel in the central nervous system
(CNS) and specifically localized to astrocyte processes. Recent studies indicate that AQP 4 …

Aquaporin 4 in astrocytes is a target for therapy in Alzheimer's disease

YL Lan, JJ Chen, G Hu, J Xu, M Xiao… - Current Pharmaceutical …, 2017 - ingentaconnect.com
Current experimental evidence points to the conclusion that aquaporin 4 (AQP4), which is
an important water-channel membrane protein found in the brain, could play major roles in …

The role of aquaporin-4 in synaptic plasticity, memory and disease

JA Hubbard, JI Szu, DK Binder - Brain research bulletin, 2018 - Elsevier
Since the discovery of aquaporins, it has become clear that the various mammalian
aquaporins play critical physiological roles in water and ion balance in multiple tissues …

The potential roles of aquaporin 4 in Alzheimer's disease

YL Lan, J Zhao, T Ma, S Li - Molecular neurobiology, 2016 - Springer
Abstract Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous
system (CNS), and it is primarily expressed in astrocytes. It has been studied in various brain …

A research update on the potential roles of aquaporin 4 in neuroinflammation

YL Lan, DY Fang, J Zhao, TH Ma, S Li - Acta Neurologica Belgica, 2016 - Springer
The presence of aquaporins (AQPs) in the brain has led to intense research on the
underlying roles of this family of proteins under both normal and pathological conditions …

The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory

JI Szu, DK Binder - Frontiers in integrative neuroscience, 2016 - frontiersin.org
Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the
central nervous system (CNS). AQP4 is widely expressed throughout the brain, especially at …

Aquaporin-4 water channel in the brain and its implication for health and disease

S Mader, L Brimberg - Cells, 2019 - mdpi.com
Aquaporin-4 (AQP4) is a water channel expressed on astrocytic endfeet in the brain. The
role of AQP4 has been studied in health and in a range of pathological conditions. Interest in …

The aquaporin-4 water channel as a potential drug target in neurological disorders

AS Verkman, AJ Smith, P Phuan… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Aquaporin-4 (AQP4) is a water transporting protein expressed at
the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis …

[HTML][HTML] Aquaporin-4 and cognitive disorders

Y Wang, C Huang, Q Guo, H Chu - Aging and disease, 2022 - ncbi.nlm.nih.gov
Abstract Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central
nervous system (CNS) and is an integral part of the glymphatic system that cannot be …

The potential roles of aquaporin 4 in amyotrophic lateral sclerosis

S Zou, YL Lan, H Wang, B Zhang, YG Sun - Neurological Sciences, 2019 - Springer
Abstract Aquaporin 4 (AQP4) is a primary water channel found on astrocytes in the central
nervous system (CNS). Besides its function in water and ion homeostasis, AQP4 has also …