Controlling nuclear RNA levels
M Schmid, TH Jensen - Nature Reviews Genetics, 2018 - nature.com
RNA turnover is an integral part of cellular RNA homeostasis and gene expression
regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of …
regulation. Whereas the cytoplasmic control of protein-coding mRNA is often the focus of …
Nuclear quality control of RNA polymerase II transcripts
M Schmid, TH Jensen - Wiley Interdisciplinary Reviews: RNA, 2010 - Wiley Online Library
Eukaryotic RNA polymerase II produces an astounding diversity of transcripts. These may
need to be 5′ capped, spliced, polyadenylated, and packaged with proteins before their …
need to be 5′ capped, spliced, polyadenylated, and packaged with proteins before their …
Surveillance-ready transcription: nuclear RNA decay as a default fate
S Bresson, D Tollervey - Open biology, 2018 - royalsocietypublishing.org
Eukaryotic cells synthesize enormous quantities of RNA from diverse classes, most of which
are subject to extensive processing. These processes are inherently error-prone, and cells …
are subject to extensive processing. These processes are inherently error-prone, and cells …
Nuclear sorting of RNA
W Garland, TH Jensen - Wiley Interdisciplinary Reviews: RNA, 2020 - Wiley Online Library
The majority of the mammalian genome is transcribed by RNA polymerase II, yielding a vast
amount of noncoding RNA (ncRNA) in addition to the standard production of mRNA. The …
amount of noncoding RNA (ncRNA) in addition to the standard production of mRNA. The …
[HTML][HTML] Nuclear RNA turnover
MJ Moore - Cell, 2002 - cell.com
Nuclear RNA Turnover: Cell Skip to Main Content Advertisement Cell This journal offers
authors two options (open access or subscription) to publish research Submit Log in Register …
authors two options (open access or subscription) to publish research Submit Log in Register …
Nuclear retention of mRNAs–quality control, gene regulation and human disease
M Wegener, M Müller-McNicoll - Seminars in Cell & Developmental …, 2018 - Elsevier
Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …
[HTML][HTML] Regulating gene expression through RNA nuclear retention
Multiple mechanisms have evolved to regulate the eukaryotic genome. We have identified
CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …
CTN-RNA, a mouse tissue-specific∼ 8 kb nuclear-retained poly (A)+ RNA that regulates the …
A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly (A)-binding protein
C Lemieux, S Marguerat, J Lafontaine, N Barbezier… - Molecular cell, 2011 - cell.com
General discard pathways eliminate unprocessed and irregular pre-mRNAs to control the
quality of gene expression. In contrast to such general pre-mRNA decay, we describe here a …
quality of gene expression. In contrast to such general pre-mRNA decay, we describe here a …
Feedback from nuclear RNA on transcription promotes robust RNA concentration homeostasis in human cells
RNA concentration homeostasis involves coordinating RNA abundance and synthesis rates
with cell size. Here, we study this in human cells by combining genome-wide perturbations …
with cell size. Here, we study this in human cells by combining genome-wide perturbations …
Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencing
SW Wang, AL Stevenson, SE Kearsey… - … and Cellular Biology, 2008 - Am Soc Microbiol
Fission yeast Cid14, a component of the TRAMP (Cid14/Trf4-Air1-Mtr4 polyadenylation)
complex, polyadenylates nuclear RNA and stimulates degradation by the exosome for RNA …
complex, polyadenylates nuclear RNA and stimulates degradation by the exosome for RNA …