Our understanding of how genomic DNA is tightly packed inside the nucleus, yet is still
accessible for vital cellular processes, has grown dramatically over recent years with …

Background Genome structures are dynamic and non-randomly organized in the nucleus of
higher eukaryotes. To maximize the accuracy and coverage of three-dimensional genome …

Chrom3D is a computational platform for 3D genome modeling that simulates the spatial
positioning of chromosome domains relative to each other and relative to the nuclear …

Dominated by microscopy for decades the nuclear genome organization field has recently
undergone a dramatic transition fuelled by new next generation sequencing technologies …

The structural organization of the genome is emerging as a crucial regulator of the cell state,
affecting gene transcription, DNA replication, and repair. Over the last twenty years …

The 3D structure of the genome plays a key role in regulatory control of the cell.
Experimental methods such as high-throughput chromosome conformation capture (Hi-C) …

New technological advances in integrated imaging, sequencing-based assays, and
computational analysis have revolutionized our view of genomes in terms of their structure …

To learn how genomic sequence influences multiscale three-dimensional (3D) genome
architecture, this manuscript presents a sequence-based deep-learning approach, Orca, that …

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

Abstract Three-dimensional (3D) genome structures vary from cell to cell even in an isogenic
sample. Unlike protein structures, genome structures are highly plastic, posing a significant …