Chromatin is hierarchically organized in human interphase nuclei. Dynamic chromatin
interactions are thought to influence gene transcription and cell fate determination. A …

Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell
type. Here, we show that this chromatin architecture can be predicted de novo using …

Dynamic compartmentalization of eukaryotic DNA into active and repressed states enables
diverse transcriptional programs to arise from a single genetic blueprint, whereas its …

Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …

Chromosome conformation capture methods are being increasingly used to study three-
dimensional genome architecture in multiple cell types and species. An important challenge …

The 3D organization of eukaryotic genomes plays an important role in genome function.
While significant progress has been made in deciphering the folding mechanisms of …

Background The sequence of a genome is insufficient to understand all genomic processes
carried out in the cell nucleus. To achieve this, the knowledge of its threedimensional …

The rapidly increasing quantity of genome-wide chromosome conformation capture data
presents great opportunities and challenges in the computational modeling and …

Probing the architecture, mechanism, and dynamics of genome folding is fundamental to our
understanding of genome function in homeostasis and disease. Most chromosome …

A decade of rapid method development has begun to yield exciting insights into the 3D
architecture of the metazoan genome and the roles it may play in regulating transcription …