Background Mounting evidence shows that urate may become a biomarker of Parkinson's
disease (PD) diagnosis and prognosis and a neuroprotectant candidate for PD therapy …

Uric acid has neuroprotective effect on Parkinson's disease (PD) by inhibiting oxidative
damage and neuronal cell death. Our previous study has shown that uric acid protected …

The nuclear factor erythroid 2-related factor 2 (Nrf2), a master transcription factor controlling
a series of cytoprotective genes, is closely associated with scavenging the reactive oxygen …

Considerable evidence has shown that elevated plasma or cerebrospinal fluid (CSF) urate
levels correlated with a reduced risk of Parkinson's disease (PD). Based on its anti-oxidative …

Higher plasma urate level is reported to be associated with a reduced risk and slower
progression of Parkinson's disease (PD). In this study, we explored the effects of urate on …

The aim of this study was to investigate whether uric acid (UA) might exert neuroprotection
via activating the nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway and regulating …

Although the pathogenic mechanisms of Parkinson's disease (PD) remain unclear, ample
empirical evidence suggests that oxidative stress is involved in the pathogenesis of this …

Recent studies indicate that NF-E2 related factor 2 (Nrf2) is a substrate for the ubiquitin-
proteasome pathway. The present study is aimed to determine whether increased protein …

The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE)
pathway exhibits protective effects in a variety of neurological diseases. However, the role of …

Aim: To determine whether Nrf2 signaling pathway activation could attenuate oxidative
stress and neuronal damage following traumatic brain injury (TBI). Methods: Controlled …