To address the long-known relationship between supernumerary centrosomes and cancer,
we have generated a transgenic mouse that permits inducible expression of the master …

As nucleators of the mitotic spindle and primary cilium, centrosomes play crucial roles in
equal segregation of DNA content to daughter cells, coordination of growth and …

Centrosomes are microtubule-organizing centers that facilitate bipolar mitotic spindle
assembly and chromosome segregation. Recognizing that centrosome amplification is a …

Centrioles organize the centrosome, and accurate control of their number is critical for the
maintenance of genomic integrity. Centriole duplication occurs once per cell cycle and is …

Centrosome amplification is frequent in cancer, but the underlying mechanisms remain
unclear. Here we report that disruption of the Kruppel-like factor 14 (KLF14) gene in mice …

Accurate control of the number of centrosomes, the major microtubule-organizing centers of
animal cells, is critical for the maintenance of genome integrity. Abnormalities in centrosome …

Centrioles are the main constituents of the mammalian centrosome and act as basal bodies
for ciliogenesis. Centrosomes organize the cytoplasmic microtubule network during …

In interphase and mitosis, centrosomes play a major role in the spatial organization of the
microtubule network. Alterations in centrosome number and structure are associated with …

We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces
centrosome amplification through the simultaneous generation of multiple procentrioles …

Introduction: Polo like kinase (PLK) is known to play a pivotal role in various cell cycle
processes to perpetuate proper division and growth of the cells. Polo like kinase-4 (PLK4) is …