A series of benzothiazole/isatin linked to 1, 2, 3-triazole moiety and terminal sulpha drugs 5a-
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …

The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …

Novel benzo [d] thiazole-based analogues were synthesized with the aim of screening their
in vitro anticancer activity. All the new derivatives 4–21 were evaluated against human …

Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …

New benzothiazole-based derivatives were synthesized in the present work with the aim of
evaluating their antitumor activity. They were in vitro tested against hepatocellular carcinoma …

Two series of thiazolidinone derivatives designing for potential EGFR and HER-2 kinase
inhibitors have been discovered. Some of them exhibited significant EGFR and HER-2 …

Multi-targeted anticancer drugs are in focus as a promising research topic. A new series of
benzothiazoles hybridized with pyrimidine moiety was designed and synthesized using the …

Introduction Epidermal growth factor receptor (EGFR) regulates several cell functions which
include cell growth, survival, multiplication, differentiation, and apoptosis. Currently, EGFR …

Two new series of diethyl 2-[2-(substituted-2-oxo-1, 2-dihydroquinolin-4-yl) hydrazono]-
succinates 6a-g and 1-(2-oxo-1, 2-dihydroquinolin-4-yl)-1H-pyrazoles 7a-f have been …

Two series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been
discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3, 4 …