[HTML][HTML] The neonatal and adult human testis defined at the single-cell level
Spermatogenesis has been intensely studied in rodents but remains poorly understood in
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
humans. Here, we used single-cell RNA sequencing to analyze human testes. Clustering …
Single-cell RNAseq analysis of testicular germ and somatic cell development during the perinatal period
Pro-spermatogonia (SG) serve as the gateway to spermatogenesis. Using single-cell RNA
sequencing (RNAseq), we studied the development of ProSG, their SG descendants and …
sequencing (RNAseq), we studied the development of ProSG, their SG descendants and …
[HTML][HTML] The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids
Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …
[HTML][HTML] A comprehensive roadmap of murine spermatogenesis defined by single-cell RNA-seq
Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …
[HTML][HTML] The adult human testis transcriptional cell atlas
Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
differentiation, alongside complex germ cell-niche interactions, to ensure long-term fertility …
[HTML][HTML] Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis
M Wang, X Liu, G Chang, Y Chen, G An, L Yan, S Gao… - Cell stem cell, 2018 - cell.com
Spermatogenesis generates mature male gametes and is critical for the proper transmission
of genetic information between generations. However, the developmental landscapes of …
of genetic information between generations. However, the developmental landscapes of …
A single-cell view of spermatogonial stem cells
K Tan, MF Wilkinson - Current opinion in cell biology, 2020 - Elsevier
Spermatogonial stem cells (SSCs) are essential for long-term spermatogenesis and are the
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …
subject of considerable clinical interest, as 'SSC therapy'has the potential to cure some …
Transcriptome profiling reveals signaling conditions dictating human spermatogonia fate in vitro
Spermatogonial stem cells (SSCs) are essential for the generation of sperm and have
potential therapeutic value for treating male infertility, which afflicts> 100 million men world …
potential therapeutic value for treating male infertility, which afflicts> 100 million men world …
[HTML][HTML] Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment
Human testis development in prenatal life involves complex changes in germline and
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
somatic cell identity. To better understand, we profiled and analyzed∼ 32,500 single-cell …
[HTML][HTML] Dynamic transcriptome profiles within spermatogonial and spermatocyte populations during postnatal testis maturation revealed by single-cell sequencing
Spermatogenesis is the process by which male gametes are formed from a self-renewing
population of spermatogonial stem cells (SSCs) residing in the testis. SSCs represent less …
population of spermatogonial stem cells (SSCs) residing in the testis. SSCs represent less …