Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era

HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

Systems biology of antibiotic production by microorganisms

JS Rokem, AE Lantz, J Nielsen - Natural Product Reports, 2007 - pubs.rsc.org
Covering: 1995 to 2006 The synthesis of secondary metabolites by microorganisms,
specifically antibiotics, is of great scientific and economic importance. The onset (control and …

Emerging evolutionary paradigms in antibiotic discovery

MG Chevrette, CR Currie - Journal of Industrial Microbiology and …, 2019 - academic.oup.com
Antibiotics revolutionized medicine and remain its cornerstone. Despite their global
importance and the continuous threat of resistant pathogens, few antibiotics have been …

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

GP Van Wezel, KJ McDowall - Natural product reports, 2011 - pubs.rsc.org
Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020 - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Chemical ecology of antibiotic production by actinomycetes

A Van der Meij, SF Worsley… - FEMS microbiology …, 2017 - academic.oup.com
Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural
products relevant for agriculture, biotechnology and medicine, including the majority of the …

Triggers and cues that activate antibiotic production by actinomycetes

H Zhu, SK Sandiford… - Journal of Industrial …, 2014 - academic.oup.com
Actinomycetes are a rich source of natural products, and these mycelial bacteria produce the
majority of the known antibiotics. The increasing difficulty to find new drugs via high …

[HTML][HTML] Concepts and methods to access novel antibiotics from actinomycetes

JJ Hug, CD Bader, M Remškar, K Cirnski, R Müller - Antibiotics, 2018 - mdpi.com
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

[HTML][HTML] Toward a new focus in antibiotic and drug discovery from the Streptomyces arsenal

S Antoraz, RI Santamaría, M Díaz, D Sanz… - Frontiers in …, 2015 - frontiersin.org
Emergence of antibiotic resistant pathogens is changing the way scientists look for new
antibiotic compounds. This race against the increased prevalence of multi-resistant strains …

Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.

G Niu, KF Chater, Y Tian, J Zhang… - FEMS Microbiology …, 2016 - academic.oup.com
Streptomyces bacteria are the major source of antibiotics and other secondary metabolites.
Various environmental and physiological conditions affect the onset and level of production …