Targeting GPX4 in human cancer: Implications of ferroptosis induction for tackling cancer resilience

J Lee, JL Roh - Cancer Letters, 2023 - Elsevier
Cancer metabolic alterations have been emphasized to protect cancer cells from cell death.
The metabolic reprogramming toward a mesenchymal state makes cancer cells resistant to …

Selenium as a cancer preventive agent

GF Combs Jr, J Lü - Selenium: its molecular biology and role in human …, 2001 - Springer
Most epidemiological studies have shown inverse associations of selenium (Se) status and
cancer risk; almost all experimental animal studies have shown that supranutritional …

Impact of trivalent arsenicals on selenoprotein synthesis

D Ganyc, S Talbot, F Konate, S Jackson… - Environmental …, 2007 - ehp.niehs.nih.gov
Background Exposure to arsenic has been associated with development of skin, lung,
bladder, liver, and kidney cancer. Recent evidence suggests that an increase in oxidative …

Aspects of a distinct cytotoxicity of selenium salts and organic selenides in living cells with possible implications for drug design

E Castellucci Estevam, K Witek, L Faulstich, MJ Nasim… - Molecules, 2015 - mdpi.com
Selenium is traditionally considered as an antioxidant element and selenium compounds
are often discussed in the context of chemoprevention and therapy. Recent studies …

[HTML][HTML] Selenium preserves keratinocyte stemness and delays senescence by maintaining epidermal adhesion

L Jobeili, P Rousselle, D Béal, E Blouin… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
Skin is constantly exposed to environmental factors such as pollutants, chemicals and ultra
violet radiation (UV), which can induce premature skin aging and increase the risk of skin …

Application of sodium selenite in the prevention and treatment of cancers

M Kieliszek, B Lipinski, S Błażejak - Cells, 2017 - mdpi.com
Selenium is an essential trace element that occurs in nature, in both inorganic and organic
forms. This element participates in numerous biochemical processes, including antioxidant …

Selenium and inflammation: underlying anti-inflammatory mechanisms

LH Duntas - Hormone and metabolic research, 2009 - thieme-connect.com
The essential trace element selenium (Se), in the form of selenoproteins, plays a pivotal role
in the antioxidant defense system of the cell. There is evidence that Se may confer benefits …

The evolving versatility of selenium in biology

R Brigelius-Flohé - Antioxidants & redox signaling, 2015 - liebertpub.com
This editorial shortly summarizes the highlights described in the Forum, novelties about
selenoproteins. Two articles describe the selenoprotein biosynthesis and the role of so far …

[引用][C] Selenite in cancer therapy: a commentary on" Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress".

A Holmgren - Free radical biology & medicine, 2006 - europepmc.org
Selenite in cancer therapy: a commentary on "Selenite induces apoptosis in sarcomatoid
malignant mesothelioma cells through oxidative stress". - Abstract - Europe PMC Sign in | Create …

Redox-active selenium in health and disease: a conceptual review

B Lipinski - Mini reviews in medicinal chemistry, 2019 - ingentaconnect.com
Although it is generally accepted that selenium (Se) is important for life, it is not well known
which forms of organic and/or inorganic Se compound are the most biologically active. In …