In Alzheimer's disease (AD), a multitude of genetic risk factors and early biomarkers are
known. Nevertheless, the causal factors responsible for initiating cognitive decline in AD …

Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders,
including Alzheimer disease (AD). Here, we asked whether early PV neuron …

Neuronal network dysfunction is increasingly recognized as an early symptom in
Alzheimer's disease (AD) and may provide new entry points for diagnosis and intervention …

Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early
pathophysiological perturbation in Alzheimer's Disease (AD). Defining early proteomic …

Alzheimer's disease (AD) results in cognitive decline and altered network activity, but the
mechanisms are unknown. We studied human amyloid precursor protein (hAPP) transgenic …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

Interneurons, key regulators of hippocampal neuronal network excitability and
synchronization, are lost in advanced stages of Alzheimer's disease (AD). Given that …

Voltage-gated ion channels are critical for neuronal integration. Some of these channels,
however, are misregulated in several neurological disorders, causing both gain-and loss-of …

Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN)
function as a precipitating factor underlying abnormalities in network synchrony, oscillatory …

One of the earliest pathophysiological perturbations in Alzheimer's Disease (AD) may arise
from dysfunction of fast-spiking parvalbumin (PV) interneurons (PV-INs). Defining early …