High glucose (HG) stimulates glomerular mesangial cell (MC) expression of extracellular
matrix, a process involving protein kinase C (PKC) isozymes and enhanced signaling by …

High glucose alters the response of mesangial cell protein kinase C isoforms to endothelin-
1. Background High glucose causes glomerular mesangial growth and increased matrix …

High ambient glucose exerts its injurious effects on renal cells through nonenzymatic and
enzymatic pathways, including altered signal transduction and upregulation of the …

Aims/hypothesis Glomerular matrix accumulation is a hallmark of diabetic nephropathy.
Recent data have linked the serine/threonine kinase protein kinase B (Akt) to matrix …

Endothelin-1 (ET-1), a potent vasoconstrictor, has been implicated in the pathogenesis of
collagen accumulation, extracellular matrix remodeling, and renal and cardiac fibrosis in …

Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We have recently
shown that epidermal growth factor receptor (EGFR) transactivation mediates high glucose …

High ambient glucose activates intracellular signaling pathways to induce cytokines such as
TGF-β1 in the extracellular matrix accumulation of diabetic nephropathy. These same …

Accumulation of glomerular matrix is a hallmark of diabetic nephropathy. The
serine/threonine kinase Akt mediates glucose-induced upregulation of collagen I in …

Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We showed that
transactivation of the epidermal growth factor receptor (EGFR) is an important mediator of …

High glucose-induced protein synthesis in the glomerular epithelial cell (GEC) is partly
dependent on reduction in phosphorylation of AMP-activated protein kinase (AMPK). We …