[HTML][HTML] NLRP3 inflammasome and its role in autoimmune diseases: A promising therapeutic target

W Ren, Y Sun, L Zhao, X Shi - Biomedicine & Pharmacotherapy, 2024 - Elsevier
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines IL-1β and …

[HTML][HTML] Role of the NLRP3 inflammasome in autoimmune diseases

Z Li, J Guo, L Bi - Biomedicine & pharmacotherapy, 2020 - Elsevier
NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that
senses foreign pathogens and endogenous danger signals. It assembles with apoptosis …

[HTML][HTML] The NLRP3 inflammasome: Contributions to inflammation-related diseases

Y Chen, X Ye, G Escames, W Lei, X Zhang, M Li… - Cellular & Molecular …, 2023 - Springer
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

The role of NLRP3 inflammasome in type 2 inflammation related diseases

S Xu, D Wang, L Tan, J Lu - Autoimmunity, 2024 - Taylor & Francis
Type 2 inflammation related diseases, such as atopic dermatitis, asthma, and allergic
rhinitis, are diverse and affect multiple systems in the human body. It is common for …

A patent review of NLRP3 inhibitors to treat autoimmune diseases

Y Xu, S Biby, B Kaur, S Zhang - Expert Opinion on Therapeutic …, 2023 - Taylor & Francis
Introduction NOD-like receptor family pyrin domain containing 3 (NLRP3) can sense a
plethora of exogenous and endogenous dangers. Upon activation, a multimeric protein …

[HTML][HTML] A narrative review of positive regulation of NLRP3 inflammasome in rheumatoid arthritis

Y Zhuang, H Wang, J Su, J Zhang… - Annals of Palliative …, 2021 - apm.amegroups.org
Objective: This paper briefly reviews the pathological characteristics and regulatory
mechanism of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome …

The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases

H Jiang, T Gong, R Zhou - Advances in immunology, 2020 - Elsevier
The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …

[HTML][HTML] Role of NLRP3 inflammasome in rheumatoid arthritis

H Yin, N Liu, KR Sigdel, L Duan - Frontiers in Immunology, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by multi-articular,
symmetrical and invasive arthritis resulting from immune system abnormalities involving T …

[HTML][HTML] NLRP3 inflammasome: checkpoint connecting innate and adaptive immunity in autoimmune diseases

Y Zhang, W Yang, W Li, Y Zhao - Frontiers in immunology, 2021 - frontiersin.org
Autoimmune diseases are a broad spectrum of human diseases that are characterized by
the breakdown of immune tolerance and the production of autoantibodies. Recently …

[HTML][HTML] NLRP3 inflammasome and its inhibitors: a review

BZ Shao, ZQ Xu, BZ Han, DF Su, C Liu - Frontiers in pharmacology, 2015 - frontiersin.org
Inflammasomes are newly recognized, vital players in innate immunity. The best
characterized is the NLRP3 inflammasome, so-called because the NLRP3 protein in the …