The NLRP3 (nucleotide-binding and oligomerization domain-like receptor family pyrin
domain-containing 3) inflammasome is a protein complex expressed in cells. It detects …

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …

Abstract The NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome
is a multimolecular complex that plays a fundamental role in inflammation. Optimal activation …

Inflammasome is a molecular platform that is formed in the cytosolic compartment to mediate
host immune responses to infection and cellular damage. Inflammasome can activate …

Inflammasomes are multiprotein intracellular complexes which are responsible for the
activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 …

IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Inflammation is a host protection mechanism that eliminates invasive pathogens from the
body. However, chronic inflammation, which occurs repeatedly and continuously over a long …

NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …