NLRP inflammasomes are a group of cytosolic multiprotein oligomer pattern recognition
receptors (PRRs) involved in the recognition of pathogen-associated molecular patterns …

Inflammation is a pivotal defense system of body. Unfortunately, when homeostasis falters,
the same inflammatory mechanism acts as a double-edged sword, and turns offensive …

The innate immune system regulates initial responses to pathogen invasion through a set of
conserved pattern recognition receptors (PRR). The best‐characterized PRRs are the Toll …

The NLRP3 inflammasome is a critical component of the innate immune system that
mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in …

Inflammation is the result of a complex network of cellular and molecular interactions and
mechanisms that facilitate immune protection against intrinsic and extrinsic stimuli …

Recent research has led to novel findings in inflammasome biology and genetics that
altered the diagnosis and management of patients with autoinflammatory syndromes caused …

Several lines of evidence point out the relevance of nucleotide-binding oligomerization
domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome …

The NLRP3 inflammasome is a key regulator of inflammation that responds to a broad range
of stimuli. The exact mechanism of activation has not been determined, but there is a …

NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been
tied with metabolic reprogramming characterized by high glycolysis and low oxidative …

NLRP3 inflammasome is an intracellular protein complex that initiates cellular injury via
assembly of NLRP3, ASC and caspase-1 in response to microbial infection and sterile …