Autoantibodies to complement components

LA Trouw, A Roos, MR Daha - Molecular immunology, 2001 - Elsevier
The complement system is a major component of innate immunity. Under normal conditions
the contribution of the complement system is beneficial, but when inappropriately activated it …

Molecules great and small: the complement system

DR Mathern, PS Heeger - … Journal of the American Society of …, 2015 - journals.lww.com
The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

Early components of the complement classical activation pathway in human systemic autoimmune diseases

KE Lintner, YL Wu, Y Yang, CH Spencer… - Frontiers in …, 2016 - frontiersin.org
The complement system consists of effector proteins, regulators, and receptors that
participate in host defense against pathogens. Activation of the complement system, via the …

Inherited complement deficiency states: implications for immunity and immunological disease

AG SjÖHolm - Apmis, 1990 - Wiley Online Library
The study of complement deficiency states and their influence on immune function has
generated new insights and still provides a challenge to continued investigation. The …