Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …

Intestinal homeostasis depends on complex interactions between the microbiota, the
intestinal epithelium and the host immune system. Diverse regulatory mechanisms …

Recently, substantial advances in the understanding of the molecular pathogenesis of
inflammatory bowel disease (IBD) have been made owing to three related lines of …

Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Genome-wide association studies have identified risk loci linked to inflammatory bowel
disease (IBD)—a complex chronic inflammatory disorder of the gastrointestinal tract. The …

The emergence of the adaptive immune system in vertebrates set the stage for evolution of
an advanced symbiotic relationship with the intestinal microbiota. The defining features of …

With ageing, normal human tissues experience an expansion of somatic clones that carry
cancer mutations,,,,,–. However, whether such clonal expansion exists in the non-neoplastic …

Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

The gut immune system has the challenge of responding to pathogens while remaining
relatively unresponsive to food antigens and the commensal microflora. In the developed …