The accurate assessment of disease risk remains a major goal in children with
medulloblastoma. Activation of the canonical Wnt/Wingless (Wnt/Wg) signalling pathway …

Medulloblastoma (MB) represents a spectrum of biologically and clinically distinct entities.
Initially described histopathologically as a small, round blue cell tumor arising in the …

Medulloblastoma (MB) is the most common malignant brain tumor in children. Although
multimodality treatment regimens including surgery, radiotherapy and chemotherapy have …

Medulloblastoma is a form of brain cancer that mainly arises during infancy and childhood.
Our understanding of this disease has transitioned rapidly; what was once thought of as a …

Medulloblastoma (MB) is the most common malignant childhood tumor of the brain.
Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced …

Introduction Molecular classification of medulloblastomas (MB) is prognostically and
therapeutically relevant and helps in better risk-stratification. Translation of this subgrouping …

Medulloblastoma is curable in approximately 70% of patients. Over the past decade,
progress in improving survival using conventional therapies has stalled, resulting in reduced …

Recent advances in cancer genomics have revolutionized the characterization and
classification of medulloblastomas. According to the current WHO guidelines …

Medulloblastoma, the most common pediatric malignant brain tumor, continues to have a
high rate of morbidity and mortality in childhood. Recent advances in cancer genomics …

Recent integrative genomic approaches have defined molecular subgroups of
medulloblastoma that are genetically and clinically distinct. Sonic hedgehog (Shh) …