Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Background Chronic cerebral hypoperfusion (CCH) is the leading cause of cerebral small
vessel disease (CSVD). CCH is strongly associated with blood–brain barrier (BBB) …

Cerebral small vessel disease (SVD) gives rise to one in five strokes worldwide and
constitutes a major source of cognitive decline in the elderly. SVD is known to occur in …

Background: We tested our hypothesis that the white matter network might mediate the effect
of amyloid and small vessel disease (SVD) on cortical thickness and/or cognition. Methods …

Cerebral small vessel disease (SVD) is a common cause of lacunar strokes, vascular
cognitive impairment (VCI) and vascular dementia. SVD is thought to result in reduced …

Cerebral small vessel disease (SVD) is a major cause of stroke and dementia.
Pathologically, three lesions are seen: small vessel arteriopathy, lacunar infarction, and …

Objective Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL), the most common inherited small‐vessel disease, is …

The role of astrocytes in dysregulation of blood-brain barrier (BBB) function following
ischemic stroke is not well understood. Here, we investigate the effects of restoring the repair …

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …

The neurovascular unit (NVU), composed of vascular cells, glial cells, and neurons, is the
minimal functional unit of the brain. The NVU maintains integrity of the blood–brain barrier …