[HTML][HTML] Pleiotropic effects of IL-33 on CD4+ T cell differentiation and effector functions

F Alvarez, JH Fritz, CA Piccirillo - Frontiers in immunology, 2019 - frontiersin.org
IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …

IL-33 in T cell differentiation, function, and immune homeostasis

M Peine, RM Marek, M Löhning - Trends in immunology, 2016 - cell.com
Recent studies have highlighted a role for the alarmin interleukin (IL)-33 in CD4+ and CD8+
T cell activation and function, and have also revealed important distinctions. The IL-33 …

New dog and new tricks: evolving roles for IL-33 in type 2 immunity

JM Lott, TL Sumpter, HR Turnquist - Journal of Leucocyte …, 2015 - academic.oup.com
IL-33 is a more recently identified member of the IL-1 cytokine family, expressed in the
nucleus of epithelial cells and released into the extracellular space following tissue damage …

The role of IL-33/ST2L signals in the immune cells

J Lu, J Kang, C Zhang, X Zhang - Immunology letters, 2015 - Elsevier
Abstract Interleukin (IL)-33 signals influence various immune cells during differentiation,
immune responses and homeostasis. As discussed in this Review, IL-33 via TI/ST2L …

Dichotomous function of IL-33 in health and disease: from biology to clinical implications

H Braun, IS Afonina, C Mueller, R Beyaert - Biochemical Pharmacology, 2018 - Elsevier
Abstract Interleukin (IL)-33 is a cytokine that is released from epithelial and endothelial cells
at barrier surfaces upon tissue stress or damage to operate as an alarmin. IL-33 has been …

IL-33 is an unconventional Alarmin that stimulates IL-2 secretion by dendritic cells to selectively expand IL-33R/ST2+ regulatory T cells

BM Matta, JM Lott, LR Mathews, Q Liu… - The Journal of …, 2014 - journals.aai.org
IL-33 is a recently characterized IL-1 family member that is proposed to function as an
alarmin, or endogenous signal of cellular damage, as well as act as a pleiotropic cytokine …

Interleukin-33 in health and disease

FY Liew, JP Girard, HR Turnquist - Nature Reviews Immunology, 2016 - nature.com
Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

[HTML][HTML] IL-33 Induces IL-9 Production in Human CD4+ T Cells and Basophils

L Blom, BC Poulsen, BM Jensen, A Hansen… - PloS one, 2011 - journals.plos.org
IL-33, an IL-1 family member and ligand for the IL-1 receptor-related protein ST2, has been
associated with induction of Th2 cytokines such as IL-4, IL-5, and IL-13. Here, we report that …

[PDF][PDF] Interleukin-33 in tissue homeostasis, injury, and inflammation

AB Molofsky, AK Savage, RM Locksley - Immunity, 2015 - cell.com
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

Disease-associated functions of IL-33: the new kid in the IL-1 family

FY Liew, NI Pitman, IB McInnes - Nature Reviews Immunology, 2010 - nature.com
Abstract Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by
many cell types following pro-inflammatory stimulation and is thought to be released on cell …