[HTML][HTML] IL-33 receptor-expressing regulatory T cells are highly activated, Th2 biased and suppress CD4 T cell proliferation through IL-10 and TGFβ release

J Siede, A Fröhlich, A Datsi, AN Hegazy, DV Varga… - PloS one, 2016 - journals.plos.org
Immunomodulatory Foxp3+ regulatory T cells (Tregs) form a heterogeneous population
consisting of subsets with different activation states, migratory properties and suppressive …

[HTML][HTML] The dynamic role of the IL-33/ST2 axis in chronic viral-infections: alarming and adjuvanting the immune response

V Mehraj, R Ponte, JP Routy - EBioMedicine, 2016 - thelancet.com
Abstract Interleukin 33 (IL-33), a member of the IL-1 family, is constitutively expressed in
epithelial and in endothelial cells at barrier sites, acting as a danger signal and adjuvanting …

IL-33 and IL-33 receptors in host defense and diseases

K Oboki, T Ohno, N Kajiwara, H Saito… - Allergology …, 2010 - jstage.jst.go.jp
ABSTRACT Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-
1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated …

Therapeutic strategies for targeting IL-33/ST2 signalling for the treatment of inflammatory diseases

WY Chen, TH Tsai, JL Yang, LC Li - Cellular Physiology and …, 2018 - karger.com
Abstract Interleukin (IL)-33, a member of the IL-1 family of cytokines, is involved in innate
and adaptive immune responses via interaction with its receptor, ST2. Activation of ST2 …

[HTML][HTML] The pleiotropic immunomodulatory functions of IL-33 and its implications in tumor immunity

C Afferni, C Buccione, S Andreone… - Frontiers in …, 2018 - frontiersin.org
Interleukin-33 (IL-33) is a IL-1 family member of cytokines exerting pleiotropic activities. In
the steady-state, IL-33 is expressed in the nucleus of epithelial, endothelial, and fibroblast …

Interleukin-33 and the function of innate lymphoid cells

AS Mirchandani, RJ Salmond, FY Liew - Trends in immunology, 2012 - cell.com
Interleukin (IL)-33 is a member of the IL-1 cytokine family that has been shown to play an
important role in the induction and effector phases of type 2 immune responses. Both innate …

Interleukin (Il)-33 and the il-1 family of cytokines—regulators of inflammation and tissue homeostasis

A Vasanthakumar, A Kallies - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Cytokines play an integral role in shaping innate and adaptive immune responses. Members
of the interleukin (IL)-1 family regulate a plethora of immune-cell-mediated processes, which …

Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion

IG Luzina, EM Pickering, P Kopach… - The Journal of …, 2012 - journals.aai.org
Expression of IL-33 is elevated in patients with pulmonary diseases, and full-length (not
proteolytically processed) IL-33 is the predominant form in the lungs in health and disease …

[HTML][HTML] IL-33 is produced by mast cells and regulates IgE-dependent inflammation

CL Hsu, CV Neilsen, PJ Bryce - PloS one, 2010 - journals.plos.org
Background IL-33 is a recently characterized IL-1 family cytokine and found to be expressed
in inflammatory diseases, including severe asthma and inflammatory bowl disease …

Lineage− Sca1+ c-Kit− CD25+ cells are IL-33–responsive Type 2 innate cells in the mouse bone marrow

A Brickshawana, VS Shapiro, H Kita… - The Journal of …, 2011 - journals.aai.org
IL-33 promotes type 2 immune responses, both protective and pathogenic. Recently, targets
of IL-33, including several newly discovered type 2 innate cells, have been characterized in …