The human Interleukin-33 (IL-33), a member of the IL-1 family, is the cytokine as a cell
endogenous alarmin, released by damaged or necrotic barrier cells (endothelial and …

IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here,
we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was …

Abstract IL-33 (IL-1F11) is a recently described member of the IL-1 family of cytokines that
stimulates the generation of cells, cytokines, and Igs characteristic of a type 2 immune …

The discovery of IL-33 as the ligand for the orphan Th2 associated receptor ST2 has
uncovered a whole range of different avenues for this pathway. Although the extracellular …

Autoimmune diseases (ADs), which are common immune-mediated inflammatory
syndromes, are characterized by an imbalance between T effector (Th) 1/Th17 cells and T …

Abstract In mice, interleukin-18 (IL-18) regulates Th1-or Th2-type immune responses
depending on the cytokine environment and effector cells involved, and the ST2-ligand, IL …

IL-33 is a chromatin-associated cytokine of the IL-1 family that has recently been linked to
many diseases, including asthma, rheumatoid arthritis, atherosclerosis, and cardiovascular …

During infection, the release of damage-associated molecular patterns, so-called “alarmins,”
orchestrates the immune response. The alarmin IL-33 plays a role in a wide range of …

BACKGROUND: IL-33, a recently discovered IL-1 family cytokine, is implicated in the
development of TH2-type responses in vivo. However, the cellular targets for IL-33 are …

Highlights•IL-33 is a crucial activator of ILC2s in innate immunity and allergic
inflammation.•The gene encoding IL-33 is a major susceptibility locus for human asthma.•IL …