IL-33/ST2 axis in autoimmune disease

L Shakerian, H Kolahdooz, M Garousi, V Keyvani… - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in
autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in …

[HTML][HTML] Expression and function of IL-33/ST2 axis in the central nervous system under normal and diseased conditions

K Fairlie-Clarke, M Barbour, C Wilson, SU Hridi… - Frontiers in …, 2018 - frontiersin.org
Interleukin-33 (IL-33) is a well-recognized immunomodulatory cytokine which plays critical
roles in tissue function and immune-mediated diseases. The abundant expression of IL-33 …

[HTML][HTML] The ST2/IL-33 axis in immune cells during inflammatory diseases

B Griesenauer, S Paczesny - Frontiers in immunology, 2017 - frontiersin.org
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …

Intraperitoneal influx of neutrophils in response to IL-33 is mast cell–dependent

M Enoksson, C Möller-Westerberg… - Blood, The Journal …, 2013 - ashpublications.org
IL-33 is a recently discovered cytokine involved in induction of Th2 responses and functions
as an alarmin. Despite numerous recent studies targeting IL-33, its role in vivo is …

[HTML][HTML] Regulatory mechanisms of IL-33-ST2-mediated allergic inflammation

H Takatori, S Makita, T Ito, A Matsuki… - Frontiers in …, 2018 - frontiersin.org
Interleukin-33 (IL-33) plays multiple roles in tissue homeostasis, prevention of parasitic
infection, and induction of allergic inflammation. Especially, IL-33-ST2 (IL-1RL1) axis has …

Interleukin 33 is a guardian of barriers and a local alarmin

NT Martin, MU Martin - Nature immunology, 2016 - nature.com
Abstract Interleukin 33 (IL-33) is a member of the IL-1 family of cytokines with a growing
number of target cells and a plethora of biological functions. Although it has commonalities …

[HTML][HTML] IL-33 in rheumatic diseases

Y Dong, J Zhong, L Dong - Frontiers in Medicine, 2021 - frontiersin.org
Interleukin-33 (IL-33) is a nuclear factor mainly expressed in barrier epithelium, endothelial
cells, and fibroblast reticular cells. Some inflammatory cells also express IL-33 under certain …

[HTML][HTML] IL33: roles in allergic inflammation and therapeutic perspectives

BCL Chan, CWK Lam, LS Tam, CK Wong - Frontiers in immunology, 2019 - frontiersin.org
Interleukin (IL)-33 belongs to IL-1 cytokine family which is constitutively produced from the
structural and lining cells including fibroblasts, endothelial cells, and epithelial cells of skin …

Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33 …

M Pichery, E Mirey, P Mercier, E Lefrancais… - The Journal of …, 2012 - journals.aai.org
IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine that
signals through the ST2 receptor and drives cytokine production in mast cells, basophils …

IL-33 and the intestine: the good, the bad, and the inflammatory

Z Hodzic, EM Schill, AM Bolock, M Good - Cytokine, 2017 - Elsevier
Abstract Interleukin-33 (IL-33) is a member of the IL-1 cytokine family that has been widely
studied since its discovery in 2005 for its dichotomous functions in homeostasis and …