[HTML][HTML] Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases

AU Lüthi, SP Cullen, EA McNeela, PJ Duriez… - Immunity, 2009 - cell.com
Summary Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization
of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via …

IL-33: a sheep in wolf's clothing?

M Gadina, CA Jefferies - Science's STKE, 2007 - science.org
Cytokines are soluble factors that regulate intercellular communication by binding to specific
cell-surface receptors and activating cellular responses. A small subset of cytokines …

The pro-tumorigenic IL-33 involved in antitumor immunity: a yin and yang cytokine

JJ Fournié, M Poupot - Frontiers in immunology, 2018 - frontiersin.org
Interleukin-33 (IL-33), considered as an alarmin released upon tissue stress or damage, is a
member of the IL-1 family and binds the ST2 receptor. First described as a potent initiator of …

Role of IL-33-ST2 pathway in regulating inflammation: current evidence and future perspectives

Y Zhou, Z Xu, Z Liu - Journal of Translational Medicine, 2023 - Springer
Abstract Interleukin (IL)-33 is an alarmin of the IL-1 superfamily localized to the nucleus of
expressing cells, such as endothelial cells, epithelial cells, and fibroblasts. In response to …

Induction of IL-33 expression and activity in central nervous system glia

CA Hudson, GP Christophi, RC Gruber… - Journal of Leucocyte …, 2008 - academic.oup.com
IL-33 is a novel member of the IL-1 cytokine family and a potent inducer of type 2 immunity,
as mast cells and Th2 CD4+ T cells respond to IL-33 with the induction of type 2 cytokines …

The enigmatic processing and secretion of interleukin-33

W Zhao, Z Hu - Cellular & molecular immunology, 2010 - nature.com
Abstract Interleukin-33 (IL-33) is the most attractive novel cytokine identified as an IL-1 family
member. IL-33 was first named NF-HEV (nuclear factor from high endothelial venules), as it …

The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders

R Saluja, ME Ketelaar, T Hawro, MK Church… - Molecular …, 2015 - Elsevier
Abstract Interleukin-33 (IL-33) is a recently discovered cytokine that belongs to the IL-1
superfamily and acts as an important regulator in several allergic disorders. It is considered …

[HTML][HTML] IL-33 biology in cancer: An update and future perspectives

WJ Yeoh, VP Vu, P Krebs - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is constitutively
expressed in the nucleus of epithelial, endothelial and fibroblast-like cells. Upon cell stress …

[PDF][PDF] 2012 ECS-ECN JUNIOR REVIEW AWARD–Mechanisms of IL-33 processing and secretion: differences and similarities between IL-1 family members

E Lefrançais, C Cayrol - European cytokine network, 2012 - researchgate.net
Interleukin-33 (IL-33) is the latest member of the IL-1 family that has become very attractive
since the discovery of its major target cells, the innate lymphoid cells type 2 (ILC2), involved …

IL-33/ST2 pathway as a rational therapeutic target for CNS diseases

LX Du, YQ Wang, GQ Hua, WL Mi - Neuroscience, 2018 - Elsevier
Abstract Interleukin (IL)-33 is a member of the interleukin-1 cytokine family that is produced
by many different types of tissues including the central nervous system (CNS). IL-33 …