Patients who survive sepsis can develop long-term immune dysfunction, with expansion of
the regulatory T (Treg) cell population. However, how Treg cells proliferate in these patients …

Interleukin-33 (IL-33) is a novel multifunctional IL-1 family cytokine. IL-33 signals via a
heterodimer composed of IL-1 receptor-related protein ST2 and IL-1 receptor accessory …

Cytokines are key mediators of the immune system, and few have been more thoroughly
studied than those of the IL-1 family. IL-1α and IL-1β are the founding members and now …

IL-33 is a newly recognized cytokine of the IL-1 cytokine family that has recently been
attributed to the epithelial “alarmin” defense system. IL-33 is released by the epithelial cells …

IL-33 has been shown to induce Th2 responses by signaling through the IL-1 receptor-
related protein, ST2L. However, the signal transduction pathways activated by the ST2L …

Interleukin-33 (IL-33) is a member of the IL-1 cytokine superfamily that potently drives
production of a variety of cytokines and contributes to the pathogenesis of inflammatory …

IL-33 is strongly involved in several inflammatory and autoimmune disorders with both pro-
and anti-inflammatory properties. However, its contribution to chronic autoimmune …

For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …

IL-33, the natural ligand of the IL-1 receptor family member ST2L, is known to enhance
experimental allergic-type inflammatory responses by costimulating the production of …

This study tests the hypothesis that activation of MAPK by physiologically relevant
concentrations of IL-33 contributes to enhanced cytokine expression by IL-12 stimulated …