The relevance of three-dimensional (3D) genome organization for transcriptional regulation
and thereby for cellular fate at large is now widely accepted. Our understanding of the …

Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …

Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in
the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects …

The 3D organization of the genome facilitates gene regulation, replication, and repair,
making it a key feature of genomic function and one that remains to be properly understood …

Rapidly developing technologies have recently fueled an exciting era of discovery in the
field of chromosome structure and nuclear organization. In addition to chromosome …

Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …

The relation between alterations in chromatin structure and changes in gene expression
during cell differentiation has served as a paradigm to understand the link between genome …

Recent burst of new technologies that allow for quantitatively delineating chromatin structure
has greatly expanded our understanding of how the genome is organized in the three …

A decade of rapid method development has begun to yield exciting insights into the 3D
architecture of the metazoan genome and the roles it may play in regulating transcription …

Over the past 10 years, the development of chromosome conformation capture (3C)
technology and the subsequent genomic variants thereof have enabled the analysis of …