The different cell types of an organism share the same DNA, but during cell differentiation
their genomes undergo diverse structural and organizational changes that affect gene …

Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …

The spatial organization of the genome is essential for the precise control of gene
expression. Recent advances in sequencing and imaging technologies allow us to explore …

Animal development depends on not only the linear genome sequence that embeds millions
of cis-regulatory elements, but also the three-dimensional (3D) chromatin architecture that …

Over a decade ago the advent of high-throughput chromosome conformation capture (Hi-C)
sparked a new era of 3D genomics. Since then the number of methods for mapping the 3D …

Eukaryotic chromosomes are organized in multiple scales, from nucleosomes to
chromosome territories. Recently, genome-wide methods identified an intermediate level of …

It has been more than a decade since the first chromosome conformation capture (3C) assay
was described. The assay was originally devised to measure the frequency with which two …

The three-dimensional folding of chromosomes compartmentalizes the genome and and
can bring distant functional elements, such as promoters and enhancers, into close spatial …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

Recent technological advances in the field of chromosome conformation capture are
facilitating tremendous progress in the ability to map the three-dimensional (3D) …