How chromosomes are organized within the tridimensional space of the nucleus and how
can this organization affect genome function have been long-standing questions on the path …

Chromosome conformation capture technologies have revealed important insights into
genome folding. Yet, how spatial genome architecture is related to gene expression and cell …

It is well known that the chromosomes are organized in the nucleus and this spatial
arrangement of genome play a crucial role in gene regulation and genome stability. Different …

Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …

The 3D organization of chromatin regulates many genome functions. Our understanding of
3D genome organization requires tools to directly visualize chromatin conformation in its …

In animals, the sequences for controlling gene expression do not concentrate just at the
transcription start site of genes, but are frequently thousands to millions of base pairs distal …

Ever since microscopes enabled visualization of the organization of eukaryotic cells,
scientists have been fascinated by the function and structure of their largest organelle, the …

In humans, nearly two meters of genomic material must be folded to fit inside each
micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA …

The three-dimensional (3D) architecture of a genome determines the spatial localization of
regulatory elements and the genes they regulate. Thus, elucidating the 3D structure of a …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …