The three-dimensional architecture of the genome affects genomic functions. Multiple
genome architectures at different length scales, including chromatin loops, domains …

The spatial organization of DNA in the cell nucleus is an emerging key contributor to
genomic function,,,,,,,,,,,. We developed 4C technology (chromosome conformation capture …

An expansive functionality and complexity has been ascribed to the majority of the human
genome that was unanticipated at the outset of the draft sequence and assembly a decade …

Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

Chromosome Conformation Capture (3C) and 3C-based technologies are constantly
evolving in order to probe nuclear organization with higher depth and resolution. One such …

The spatial organization of chromosomes inside the cell nucleus is still poorly understood.
This organization is guided by intra-and interchromosomal contacts and by interactions of …

Genetic and epigenetic inheritance through mitosis is critical for dividing cells to maintain
their state. This process occurs in the context of large-scale re-organization of chromosome …

Chromatin is organized in the nucleus via CTCF loops and compartmental domains. Here,
we compare different cell types to identify distinct paradigms of compartmental domain …

Abstract Chromosome conformation capture (3C)-based techniques have revolutionized the
field of nuclear organization, partly replacing DNA FISH as the method of choice for studying …

The architecture of interphase chromosomes is important for the regulation of gene
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …