Mammalian gene expression patterns are controlled by regulatory elements, which interact
within topologically associating domains (TADs). The relationship between activation of …

Compartmentalization is a ubiquitous feature of cellular function. In the nucleus, early
observations revealed a non-random spatial organization of the genome with a large-scale …

The three-dimensional configuration of DNA is integral to all nuclear processes in
eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide …

While nuclear compartmentalization is an essential feature of three-dimensional genome
organization, no genomic method exists for measuring chromosome distances to defined …

Genomes are more than linear sequences. In vivo they exist as elaborate physical
structures, and their functional properties are strongly determined by their cellular …

Recent advances in fluorescence in situ hybridization and three-dimensional microscopy
have revealed a high degree of large-scale order in the nucleus, indicating that the position …

Due to recent advances in experimental and theoretical approaches, the dynamic three-
dimensional organization (3D) of the nucleus has become a very active area of research in …

Background Embryonic development proceeds through finely tuned reprogramming of the
parental genomes to form a totipotent embryo. Cells within this embryo will then differentiate …

Understanding nuclear architecture is indispensable for understanding the cell-type-
dependent orchestration of active and silent genes and other nuclear functions, such as …

Recent methodological advancements in microscopy and DNA sequencing-based methods
provide unprecedented new insights into the spatio-temporal relationships between …