Chromosome Conformation Capture, or 3C, is a pioneering method for investigating the
three-dimensional structure of chromatin. 3C is used to analyze long-range looping …

Recent developments in live-cell imaging are challenging our stereotyped view of the fixed
cell nucleus. The emerging picture is that nuclear processes may rely on a constant flow of …

The functional significance of changes in nuclear structure and organization in transformed
cells remains one of the most enigmatic questions in cancer biology. In this review, we …

Improvements in fluorescence microscopy have allowed us to explore the three-dimensional
organization of the nucleus in ways that were impossible ten years ago, revealing …

A cell fraction that would today be termed “the nuclear matrix” was first described and
patented in 1948 by Russian investigators. In 1974 this fraction was rediscovered and …

Genomes are defined by their primary sequence. The functional properties of genomes,
however, are determined by far more complex mechanisms and depend on multiple layers …

Although the nonrandom nature of interphase chromosome arrangement is widely accepted,
how nuclear organization relates to genomic function remains unclear. Nuclear …