Summary Interleukin-12 and interleukin-23 have distinct roles in mediating host defense and
autoimmune inflammation. Although targeting interleukin-12 and interleukin-23 …

The interleukin (IL)-12 family of cytokines, including IL-12 and IL-23, are important mediators
of immune-mediated inflammatory diseases such as psoriasis, multiple sclerosis …

Purpose IL-23 is a central proinflammatory cytokine with a wide range of influence over
immune response. It is implicated in several autoimmune diseases due to the infinite …

The discovery of the biological functions of the interleukin-23/-17 axis led to the identification
of IL-23 and IL-17 as important participants in the pathogenesis of several immune-mediated …

Interleukin-12 was considered to be the driving force behind pathological conditions
associated with several autoimmune disease models, including experimental autoimmune …

Abstract Interleukin 35 (IL-35) is the most recently identified member of the IL-12 family of
cytokines and offers the potential to be a target for new therapies for autoimmune …

Interleukin-25 (IL-25), the newest member of the IL-17 cytokine family, initiates, promotes,
and augments Th2 cell-mediated immune responses, thereby contributing to allergic …

Therapies targeting either interleukin (IL)-23 or IL-17 have shown promise in treating T
helper 17 (Th17)–driven autoimmune diseases. Although IL-23 is a critical driver of IL-17 …

Abstract Interleukin (IL)-12 and IL-23 play important roles in the development of
experimental autoimmune disease models and numerous afflictions affecting humans …

Abstract Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor
complexes containing the common gamma (γ c) chain for signaling. IL-15 plays important …