Sepsis is a syndrome involving systemic inflammation as well as an infectious focus.
Accordingly, the host immune response to sepsis involves complex leukocyte interplay that …

Sepsis, a disease of divergent pro-and anti-inflammatory–mediated pathways, has a high
prevalence of morbidity and mortality, yet an understanding of potential unifying mediators …

Macrophages facilitate critical functions in regulating pathogen clearance and immune
homeostasis in tissues. The remarkable functional diversity exhibited by macrophage …

Rationale: The immune response in sepsis is characterized by overt immune dysfunction.
Studies indicate immunostimulation represents a viable therapy for patients. One study …

Sepsis is a worldwide health priority characterized by the occurrence of severe
immunosuppression associated with increased risk of death and secondary infections …

The sepsis syndrome represents an improper immune response to infection and is
associated with unacceptably high rates of mortality and morbidity. The interactions between …

Abstract Interleukin (IL)-10 is a potent immunosuppressant of monocyte/macrophage
function and may help control the inflammatory response induced by bacterial infection. To …

Abstract Interleukin (IL)-10 is a pleiotropic cytokine produced by both T cells and
macrophages and possesses both anti-inflammatory and immunosuppressive properties. IL …

Septic peritonitis remains a major cause of death. Neutrophils and inflammatory monocytes
are principal components of the innate immune system and are essential for defense against …

The dysregulated sepsis-induced cytokine storm evoked during systemic infection consists
of biphasic and interconnected pro-and anti-inflammatory responses. The contrasting …