Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

In mammals, all somatic development originates from lineage segregation in early embryos.
However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell …

BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

Chromatin structure is intimately connected with gene expression and cell identity. Here we
review recent advances in the field and discuss how establishment of cell identity during …

Extensive epigenetic reprogramming occurs during preimplantation embryo development.
However, it remains largely unclear how the drastic epigenetic reprogramming contributes to …

Chromatin, the template for epigenetic regulation, is a highly dynamic entity that is constantly
reshaped during early development and differentiation. Epigenetic modification of chromatin …

Fertilization of the oocyte by the sperm results in the formation of a totipotent zygote, in which
the maternal and paternal chromatin is enclosed in two pronuclei undergoing distinct …