Autoimmune diseases are common diseases in which loss of tolerance within the immune
system results in pathologic immune responses that target either cellular or organ-specific …

Autoimmune diseases are the result of specific immune responses directed against
structures of the self (Burnet and Fenner, 1949). The organism possesses powerful …

Converging experimental evidence indicates that the clinical expression of autoimmunity is
under the control of T cell‐mediated immunoregulatory circuits. Several types of suppressor …

Autoimmune diseases are a heterogeneous group of disorders where multiple alterations in
the immune system result in a spectrum of syndromes that either target specific organs or …

Autoimmune reactions reflect an imbalance between effector and regulatory immune
responses, typically develop through stages of initiation and propagation, and often show …

Complex autoimmune diseases are chronic conditions initiated by a loss of immunological
tolerance to self-antigens. Despite many years of intense investigation, the etiopathogenic …

Progress in defining the genetics of autoimmune disease has been dramatically enhanced
by large scale genetic studies. Genome-wide approaches, examining hundreds or for some …

Highlights•Metabolic programs play a key role in immune response.•Defects in metabolic
pathways associated with loss of immunological tolerance.•Systemic metabolic status …

Extraordinary technical advances in the field of human genetics over the past few years
have catalyzed an explosion of new information about the genetics of human autoimmunity …

The immune system specifically recognizes and eliminates foreign antigens and, thus,
protects integrity of the host. During maturation of the immune system, tolerance …