Manufacturing of human extracellular vesicle-based therapeutics for clinical use

M Gimona, K Pachler, S Laner-Plamberger… - International journal of …, 2017 - mdpi.com
Extracellular vesicles (EVs) derived from stem and progenitor cells may have therapeutic
effects comparable to their parental cells and are considered promising agents for the …

Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation

M Maumus, P Rozier, J Boulestreau… - … in Bioengineering and …, 2020 - frontiersin.org
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …

Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications

S Rani, AE Ryan, MD Griffin, T Ritter - Molecular Therapy, 2015 - cell.com
Mesenchymal stem (stromal) cells (MSCs) are multipotent cells with the ability to differentiate
into several cell types, thus serving as a cell reservoir for regenerative medicine. Much of the …

From mesenchymal stromal cells to engineered extracellular vesicles: a new therapeutic paradigm

J Johnson, M Shojaee, J Mitchell Crow… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) are multipotent cells obtained from many tissues
including bone marrow, adipose tissue, umbilical cord, amniotic fluid, and placenta. MSCs …

Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions

C Almeria, S Kreß, V Weber, D Egger, C Kasper - Cell & Bioscience, 2022 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in
physiological as well as pathological processes by functioning as vehicles for the delivery of …

[HTML][HTML] Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing

E Rohde, K Pachler, M Gimona - Cytotherapy, 2019 - Elsevier
Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) may deliver
therapeutic effects that are comparable to their parental cells. MSC-EVs are promising …

Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications

A Gowen, F Shahjin, S Chand, KE Odegaard… - Frontiers in cell and …, 2020 - frontiersin.org
Stem cell therapy has garnered much attention and application in the past decades for the
treatment of diseases and injuries. Mesenchymal stem cells (MSCs) are studied most …

Scaled isolation of mesenchymal stem/stromal cell‐derived extracellular vesicles

V Börger, S Staubach, R Dittrich… - Current protocols in …, 2020 - Wiley Online Library
Mesenchymal stem/stromal cells (MSCs) provide therapeutic effects in many diseases.
Contrary to initial hypotheses, they act in a paracrine rather than a cellular manner. To this …

Mesenchymal stem cell-derived extracellular vesicles for therapeutic use and in bioengineering applications

C McLaughlin, P Datta, YP Singh, A Lo, S Horchler… - Cells, 2022 - mdpi.com
Extracellular vesicles (EVs) are small lipid bilayer-delimited particles that are naturally
released from cells into body fluids, and therefore can travel and convey regulatory functions …

An analysis of mesenchymal stem cell-derived extracellular vesicles for preclinical use

A Tieu, MM Lalu, M Slobodian, C Gnyra… - ACS …, 2020 - ACS Publications
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) can reduce inflammation,
promote healing, and improve organ function, thereby providing a potential “cell-free” …