Clinical trials for neuroprotection in ALS

G Siciliano, C Carlesi, L Pasquali… - CNS & Neurological …, 2010 - ingentaconnect.com
Owing to uncertainty on the pathogenic mechanisms underlying motor neuron degeneration
in amyotrophic lateral sclerosis (ALS) riluzole remains the only available therapy, with only …

Current Therapy in Amyotrophic lateral sclerosis (ALS): a review on Past and Future Therapeutic Strategies

Y Wei, S Zhong, H Yang, X Wang, B Lv, Y Bian… - European Journal of …, 2024 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the first
and second motoneurons (MNs), associated with muscle weakness, paralysis and finally …

Prospects for the pharmacotherapy of amyotrophic lateral sclerosis: old strategies and new paradigms for the third millennium

BW Festoff, Z Suo, BA Citron - CNS drugs, 2003 - Springer
Biomedical researchers interested in amyotrophic lateral sclerosis (ALS) must invoke newly
developing technologies if we are to discover pharmaceutical treatments that will help a …

Current and prospective disease-modifying therapies for amyotrophic lateral sclerosis

JA Morren, N Galvez-Jimenez - Expert Opinion on Investigational …, 2012 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a devastating illness of unclear etiology
affecting motor neurons. It causes unremitting muscle paralysis, atrophy and death usually …

Pharmacotherapy for amyotrophic lateral sclerosis: a review of approved and upcoming agents

SA Johnson, T Fang, F De Marchi, D Neel… - Drugs, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …

Emerging drugs for the treatment of amyotrophic lateral sclerosis: a focus on recent phase 2 trials

A Barp, F Gerardi, A Lizio, VA Sansone… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative
disease involving both upper and lower motor neurons and resulting in increasing disability …

Therapeutic neuroprotective agents for amyotrophic lateral sclerosis

RS Pandya, H Zhu, W Li, R Bowser… - Cellular and molecular …, 2013 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal chronic neurodegenerative disease whose
hallmark is proteinaceous, ubiquitinated, cytoplasmic inclusions in motor neurons and …

Current view and perspectives in amyotrophic lateral sclerosis

S Mathis, P Couratier, A Julian, P Corcia… - Neural Regeneration …, 2017 - journals.lww.com
Amyotrophic lateral sclerosis (ALS), identified as a distinct clinical entity by Charcot since the
end of the nineteenth century, is a devastating and fatal neurodegenerative disorder that …

The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future

HJ Wobst, KL Mack, DG Brown… - Medicinal research …, 2020 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by
progressive loss of muscle function. It is the most common adult‐onset form of motor neuron …

Diagnosis, pathogenesis and therapeutic targets in amyotrophic lateral sclerosis

J Costa, C Gomes… - CNS & Neurological …, 2010 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of the motor
system. The diagnosis is clinical, but additional investigations such as electromyography …