The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation
and development; a similar molecule in B cells has not yet been identified. Here, we report …

NTAL (non-T cell activation linker)/LAB (linker for activation of B cells) is a LAT (linker for
activation of T cells)-like molecule that is expressed in B cells, mast cells, natural killer cells …

Linker for activation of B cells (LAB, also called NTAL; a product of wbscr5 gene) is a newly
identified transmembrane adaptor protein that is expressed in B cells, NK cells, and mast …

By mediating non-covalent protein–protein interactions, adaptors organize and assemble
the multimolecular signalling complexes that coordinate intracellular programs leading to …

LAB (linker for activation of B cells), also known as NTAL (non-T cell activation linker), is a
LAT (linker for activation of T cells)-like adaptor protein that is expressed in B, NK, and mast …

The adaptor molecule SLAP and E3 ubiquitin ligase c-Cbl each regulate expression of T cell
receptor (TCR)–CD3 on thymocytes. Here we provide genetic and biochemical evidence …

Adaptor proteins have important functions in coupling stimulation through immunoreceptors
with downstream events. The adaptor linker for activation of B cells (LAB)/non-T cell …

The avidity of BCRs and TCRs influences signal strength during processes of lymphocyte
development. Avidity is determined by both the intrinsic affinity for Ag and surface levels of …

Src-like adaptor protein (SLAP) and c-Cbl recently have been shown to cooperate in
regulating T cell receptor (TCR) levels in developing T cells. SLAP also is expressed in …

Abstract SLP-65−/− mice display a partial block at the pre-B cell stage of development. Here,
we show that LAT is required for the differentiation of SLP-65−/− pre-B cells. We show that …