Insulin resistance is a common disorder caused by a wide variety of physiological insults,
some of which include poor diet, inflammation, anti-inflammatory steroids, hyperinsulinemia …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Insulin inhibits systemic nonesterified fatty acid (NEFA) flux to a greater degree than glucose
or any other metabolite. This remarkable effect is mainly due to insulin-mediated inhibition of …

The primary genetic, environmental, and metabolic factors responsible for causing insulin
resistance and pancreatic β-cell failure and the precise sequence of events leading to the …

Type 2 diabetes is characterized by hyperlipidemia, hyperinsulinemia, and insulin
resistance. The aim of this study was to investigate whether acute hyperlipidemia-induced …

Type 2 diabetes arises from a combination of impaired insulin action and defective
pancreatic β-cell function. Classically, the two abnormalities have been viewed as distinct …

Insulin resistance is a major characteristic of obesity and type 2 diabetes, and develops in
multiple organs, including the heart. Compared with its role in other organs, the …

Insulin resistance is a common feature of obesity and type 2 diabetes, but novel approaches
of diabetes subtyping (clustering) revealed variable degrees of insulin resistance in people …

The development of insulin resistance (IR) in the liver is a key pathophysiologic event in the
development of type 2 diabetes. Although insulin loses its ability to suppress glucose …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …