Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …

Obesity is a major health risk factor, and obesity-induced morbidity and complications
account for huge costs for affected individuals, families, healthcare systems, and society at …

Insulin resistance, when combined with impaired insulin secretion, contributes to the
development of type 2 diabetes. Insulin resistance is characterized by a decrease in the …

DANISH MEDICAL JOURNAL 2 insulin resistance in genetic and acquired forms of
lipodystrophies and insulin receptorpathies (5), including rare mutations in genes of post …

The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …

The incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise
world-wide. The liver is a central insulin-responsive metabolic organ that governs whole …

Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to
suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly …

Insulin signalling is uniquely required for storing energy as fat in humans. While de novo
synthesis of fatty acids and triacylglycerol occurs mostly in liver, adipose tissue is the primary …

Impaired glucose tolerance (IGT) is characterized by insulin resistance. Recently, defects in
the insulin-signaling cascade have been implicated in the pathogenesis of insulin …