The cDC1 subset of classical dendritic cells is specialized for priming CD8 T cell responses
through the process of cross-presentation. The molecular mechanisms of cross-presentation …

Conventional dendritic cells (cDC) are antigen-presenting cells comprising cDC1 and cDC2,
responsible for priming naive CD8+ and CD4+ T cells, respectively. Recent studies have …

Conventional dendritic cells (cDCs) are potent antigen-presenting cells that consist of
developmentally, phenotypically, and functionally distinct subsets. Following immunization …

Follicular dendritic cells and macrophages have been strongly implicated in presentation of
native Ag to B cells. This property has also occasionally been attributed to conventional …

Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of
antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 …

Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and
functional features, leading to blurring of the boundaries between these two cell lineages …

During the initiation of adaptive immune responses, millions of lymphocytes must be
scanned to find the few cognate clones. The activation mechanisms of CD4 T cells have …

Conventional dendritic cells expressing the XCR1 chemokine receptor (cDC1s) excel at
cross-presentation. Here, we developed and used a mouse model in which a Cre …

Dendritic cells are a specialized subset of hematopoietic cells essential for mounting
immunity against tumors and infectious disease as well as inducing tolerance for …

Conventional type 1 dendritic cells (cDC1) are thought to perform antigen cross-
presentation, which is required to prime CD8+ T cells,, whereas cDC2 are specialized for …