Local promotion of B10 function alleviates experimental periodontitis bone loss through antagonizing RANKL‐expressing neutrophils

G Cao, X Zhang, Y Song, Y Sun, H Ling… - Journal of …, 2021 - Wiley Online Library
Background Persistent host immune responses initiated by oral bacteria protect host against
infection but may also elicit the process of sustained periodontal inflammation and …

B10 cells alleviate periodontal bone loss in experimental periodontitis

Y Wang, X Yu, J Lin, Y Hu, Q Zhao, T Kawai… - Infection and …, 2017 - Am Soc Microbiol
ABSTRACT B10 cells can regulate inflammatory responses in innate immunity. Toll-like
receptors (TLRs) play an important role in B cell-mediated immune responses in periodontal …

IL-10 secreting B cells regulate periodontal immune response during periodontitis

T Shi, Y Jin, Y Miao, Y Wang, Y Zhou, X Lin - Odontology, 2020 - Springer
Periodontitis is a disease caused by periodontopathogens and is characterized by
periodontal inflammation and alveolar bone resorption. As has been proven, host immune …

Improved RANKL expression and osteoclastogenesis induction of CD27+ CD38− memory B cells: A link between B cells and alveolar bone damage in periodontitis

Y Han, Y Jin, Y Miao, T Shi, X Lin - Journal of Periodontal …, 2019 - Wiley Online Library
Background and Objective Periodontitis is a bacteria‐induced disease that often leads to
alveolar bone damage. Its mechanisms were considered to be complicated, involving an …

CD25+ B cells produced IL‐35 and alleviated local inflammation during experimental periodontitis

Y Han, C Yu, Y Yu, L Bi - Oral diseases, 2022 - Wiley Online Library
Background and objective Host immunity is crucial during periodontal inflammations. B cells
are considered to have a function of immunoregulation, and TLRs are considered to be …

Regulatory B cells induced by interleukin‐35 inhibit inflammation and alveolar bone resorption in ligature‐induced periodontitis

S Li, L Su, Q Luan, G Liu, W Zeng… - Journal of …, 2023 - Wiley Online Library
Abstract Background Regulatory B cells (Bregs) have been reported to suppress immune
responses and alveolar bone loss in murine periodontitis models. These cells could be …

Local induction of B cell interleukin-10 competency alleviates inflammation and bone loss in ligature-induced experimental periodontitis in mice

P Yu, Y Hu, Z Liu, T Kawai, MA Taubman… - Infection and …, 2017 - Am Soc Microbiol
ABSTRACT Interleukin-10 (IL-10)-producing B cells (B10 cells) play a critical role in the
immune system balance by negatively regulating inflammatory responses. This study was …

B-cell deficiency exacerbates inflammation and bone loss in ligature-induced experimental periodontitis in mice

W Zeng, G Liu, Q Luan, C Yang, S Li… - Journal of Inflammation …, 2021 - Taylor & Francis
Objective Periodontitis, one of the most prevalent chronic oral infectious diseases in
humans, is induced by the breakdown in the balance between the biofilm and host immune …

Improved RANKL production by memory B cells: A way for B cells promote alveolar bone destruction during periodontitis

YK Han, Y Jin, YB Miao, T Shi, XP Lin - International Immunopharmacology, 2018 - Elsevier
Periodontitis is a bacteria-induced disease that always clinically defined as loss of
attachment, periodontal pocket and bone loss. Its mechanisms were considered to be …

IL‐22–expressing CD4+AhR+ T lymphocytes are associated with RANKL‐mediated alveolar bone resorption during experimental periodontitis

G Monasterio, V Budini, B Fernández… - Journal of …, 2019 - Wiley Online Library
Background and Objective Over the past few years, the importance of interleukin‐22 (IL‐22)
and T‐helper (Th) 22 lymphocytes in the pathogenesis of periodontitis has become …