A general [18 F] AlF radiochemistry procedure on two automated synthesis platforms

L Allott, C Da Pieve, DR Turton, G Smith - Reaction Chemistry & …, 2017 - pubs.rsc.org
The aluminium fluoride-18 ([18F] AlF) radiolabelling procedure has generated great interest
because it is a simple, one-pot method that can be used to directly radiolabel small …

[HTML][HTML] Custom-built automated radiosynthesis platform for Al [18F] F radiochemistry and its application for clinical production

Z Fu, L Yu, Y Gai, F Gao, Q Liu, L Wang, Z Liu - Chemical Engineering …, 2023 - Elsevier
The construction of fully automated Al [18 F] F radiochemistry can enhance the
reproducibility and reliability of Al [18 F] F-based radiopharmaceuticals while promoting …

A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [18F]fluoride: Will [18F]AlF Replace 68Ga for Metal Chelate Labeling?

C Fersing, A Bouhlel, C Cantelli, P Garrigue… - Molecules, 2019 - mdpi.com
Due to its ideal physical properties, fluorine-18 turns out to be a key radionuclide for positron
emission tomography (PET) imaging, for both preclinical and clinical applications. However …

One-pot and one-step automated radio-synthesis of [18F]AlF-FAPI-74 using a multi purpose synthesizer: a proof-of-concept experiment

S Naka, T Watabe, T Lindner, J Cardinale… - EJNMMI …, 2021 - Springer
Background Fibroblast activation protein (FAP) is overexpressed in the stroma of many types
of cancer.[18F] AlF-FAPI-74 is a positron emission tomography tracer with high selectivity for …

Fully automated radiosynthesis of [18 F] fluoro-C-glyco-c (RGDfC): exploiting all the abilities of the AllInOne synthesizer

C Collet, T Vucko, J Ariztia, G Karcher… - Reaction Chemistry & …, 2019 - pubs.rsc.org
Radiolabelled peptides are crucial tools for biomedical research purposes. Peptides are
usually labeled with fluorine-18 via an indirect prosthetic group approach, which requires a …

New lyophilized kit for rapid radiofluorination of peptides

WJ McBride, CA D'Souza, H Karacay… - Bioconjugate …, 2012 - ACS Publications
Radiolabeling compounds with positron-emitting radionuclides often involves a time-
consuming, customized process. Herein, we report a simple lyophilized kit formulation for …

Rapid 18 F-radiolabeling of peptides from [18 F] fluoride using a single microfluidics device

RC Cumming, DE Olberg, JL Sutcliffe - Rsc Advances, 2014 - pubs.rsc.org
To date the majority of 18F-peptide radiolabeling approaches are multi-step, low yielding
and time-consuming processes. Given the short half-life of 18F (109.8 min), it is critical that …

“In‐loop” 18F‐fluorination: A proof‐of‐concept study

K Dahl, A Garcia, NA Stephenson… - Journal of Labelled …, 2019 - Wiley Online Library
There is a great demand to develop more cost‐efficient and robust manufacturing processes
for fluorine‐18 (18F) labelled compounds and radiopharmaceuticals. Herein, we present to …

A simple and rapid automated radiosynthesis of [18F]fluoroacetate

G Tang, X Tang, M Wang, B Li… - Journal of Labelled …, 2008 - Wiley Online Library
Two fully automated synthetic procedures of [18F] fluoroacetate ([18F] FAC) have been
developed using a modified commercial TRACERlab FXFN synthesizer. One was a two …

Neither azeotropic drying, nor base nor other additives: a minimalist approach to 18 F-labeling

R Richarz, P Krapf, F Zarrad, EA Urusova… - Organic & …, 2014 - pubs.rsc.org
A novel, efficient, time-saving and reliable radiolabeling procedure via nucleophilic
substitution with [18F] fluoride is described. Different radiolabeled aliphatic and aromatic …