The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer
JH Kim, SM Dhanasekaran, JR Prensner… - Genome …, 2011 - genome.cshlp.org
Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of
prostate cancer progression. We mapped the global DNA methylation patterns in select …
prostate cancer progression. We mapped the global DNA methylation patterns in select …
DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases
MJ Aryee, W Liu, JC Engelmann, P Nuhn… - Science translational …, 2013 - science.org
Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations
in epigenetic marks, including DNA methylation, are potentially heritable, they can also be …
in epigenetic marks, including DNA methylation, are potentially heritable, they can also be …
Epigenome-wide tumor DNA methylation profiling identifies novel prognostic biomarkers of metastatic-lethal progression in men diagnosed with clinically localized …
S Zhao, MS Geybels, A Leonardson, R Rubicz… - Clinical Cancer …, 2017 - AACR
Abstract Purpose: Aside from Gleason sum, few factors accurately identify the subset of
prostate cancer patients at high risk for metastatic progression. We hypothesized that …
prostate cancer patients at high risk for metastatic progression. We hypothesized that …
DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer
Y Kobayashi, DM Absher, ZG Gulzar… - Genome …, 2011 - genome.cshlp.org
Candidate gene-based studies have identified a handful of aberrant CpG DNA methylation
events in prostate cancer. However, DNA methylation profiles have not been compared on a …
events in prostate cancer. However, DNA methylation profiles have not been compared on a …
Genome-wide plasma DNA methylation features of metastatic prostate cancer
A Wu, P Cremaschi, D Wetterskog… - The Journal of …, 2020 - Am Soc Clin Investig
Tumor DNA circulates in the plasma of cancer patients admixed with DNA from
noncancerous cells. The genomic landscape of plasma DNA has been characterized in …
noncancerous cells. The genomic landscape of plasma DNA has been characterized in …
Epigenomic alterations in localized and advanced prostate cancer
PC Lin, EG Giannopoulou, K Park, JM Mosquera… - Neoplasia, 2013 - Elsevier
Although prostate cancer (PCa) is the second leading cause of cancer death among men
worldwide, not all men diagnosed with PCa will die from the disease. A critical challenge …
worldwide, not all men diagnosed with PCa will die from the disease. A critical challenge …
The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors
Metastatic prostate cancer remains a major clinical challenge and metastatic lesions are
highly heterogeneous and difficult to biopsy. Liquid biopsy provides opportunities to gain …
highly heterogeneous and difficult to biopsy. Liquid biopsy provides opportunities to gain …
Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer
D Brocks, Y Assenov, S Minner, O Bogatyrova… - Cell reports, 2014 - cell.com
Despite much evidence on epigenetic abnormalities in cancer, it is currently unclear to what
extent epigenetic alterations can be associated with tumors' clonal genetic origins. Here, we …
extent epigenetic alterations can be associated with tumors' clonal genetic origins. Here, we …
A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis
N Ashour, JC Angulo, G Andrés, R Alelú… - The …, 2014 - Wiley Online Library
BACKGROUND DNA hypermethylation has emerged as a novel molecular biomarker for the
evaluation of prostate cancer diagnosis and prognosis. Defining the specific gene …
evaluation of prostate cancer diagnosis and prognosis. Defining the specific gene …
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