HAND2 target gene regulatory networks control atrioventricular canal and cardiac valve development
F Laurent, A Girdziusaite, J Gamart, I Barozzi… - Cell reports, 2017 - cell.com
The HAND2 transcriptional regulator controls cardiac development, and we uncover
additional essential functions in the endothelial to mesenchymal transition (EMT) underlying …
additional essential functions in the endothelial to mesenchymal transition (EMT) underlying …
HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis
M Xia, W Luo, H Jin, Z Yang - Development, 2019 - journals.biologists.com
During embryogenesis, epithelial organization is the prerequisite for organogenesis, in
particular, for establishing the tubular structure. Recent studies provided hints about …
particular, for establishing the tubular structure. Recent studies provided hints about …
Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development
RM Barnes, BA Firulli, NJ VanDusen… - Circulation …, 2011 - Am Heart Assoc
Rationale: The basic helix–loop–helix (bHLH) transcription factors Hand1 and Hand2 are
essential for embryonic development. Given their requirement for cardiogenesis, it is …
essential for embryonic development. Given their requirement for cardiogenesis, it is …
Single cell evaluation of endocardial Hand2 gene regulatory networks reveals HAND2-dependent pathways that impact cardiac morphogenesis
The transcription factor HAND2 plays essential roles during cardiogenesis. Hand2
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
endocardial deletion (H2CKO) results in tricuspid atresia or double inlet left ventricle with …
[HTML][HTML] Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development
KL Holler, TJ Hendershot, SE Troy, JW Vincentz… - Developmental …, 2010 - Elsevier
The basic helix–loop–helix DNA binding protein Hand2 has critical functions in cardiac
development both in neural crest-derived and mesoderm-derived structures. Targeted …
development both in neural crest-derived and mesoderm-derived structures. Targeted …
Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium
NJ VanDusen, J Casanovas, JW Vincentz, BA Firulli… - Cell reports, 2014 - cell.com
The basic-helix-loop-helix (bHLH) transcription factor Hand2 plays critical roles during
cardiac morphogenesis via expression and function within myocardial, neural crest, and …
cardiac morphogenesis via expression and function within myocardial, neural crest, and …
Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration
YL Schindler, KM Garske, J Wang, BA Firulli… - …, 2014 - journals.biologists.com
Embryonic heart formation requires the production of an appropriate number of
cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of …
cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of …
HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure
BA Firulli, RM George, J Harkin, KP Toolan… - Cardiovascular …, 2020 - academic.oup.com
Aims To examine the role of the basic Helix-loop-Helix (bHLH) transcription factor HAND1 in
embryonic and adult myocardium. Methods and results Hand1 is expressed within the …
embryonic and adult myocardium. Methods and results Hand1 is expressed within the …
Cardiac neural crest expression of Hand2 regulates outflow and second heart field development
Y Morikawa, P Cserjesi - Circulation research, 2008 - Am Heart Assoc
The cardiac neural crest (cNC) lineage plays key roles in heart development by directly
contributing to heart structures and regulating development of other heart lineages. The …
contributing to heart structures and regulating development of other heart lineages. The …
The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
DG McFadden, AC Barbosa, JA Richardson… - 2005 - journals.biologists.com
The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …
spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at …