Background: Rapid forced expiratory volume in 1 s (FEV1) decliners have been considered
a unique subgroup of patients with chronic obstructive pulmonary disease (COPD). Rapid …

Background Early diagnosis of COPD is often not achieved due to limited recognition and
limited access to the pulmonary function test. Our hypothesis was that lung function decline …

Objective: We aim to make use of clinical spirometry data in order to identify individual
COPD-patients with divergent trajectories of lung function over time. Study Design and …

The wide distribution of individual rates of decline in FEV 1 includes especially rapid and
slow declines. Future research is needed to identify biomarkers that both are predictive of a …

Long-term decline in lung function is generally considered to be progressive in individuals
with established chronic obstructive pulmonary disease (COPD), despite the presence of …

Background: Early identification of patients with COPD and prone to more rapid decline in
lung function is of particular interest from both a prognostic and therapeutic point of view …

For decades, the natural history of chronic obstructive pulmonary disease (COPD) has been
defined by the excess decline in lung function induced by tobacco smoking, with FEV1 …

Background Estimates for lung function decline in chronic obstructive pulmonary disease
(COPD) have differed by study setting and have not been described in a UK primary care …

Progressive decline in lung function has been widely accepted as the hallmark of chronic
obstructive pulmonary disease (COPD); however, recent evidence indicates that the rate of …

Background Forced expiratory volume in 1 second (FEV 1)/forced vital capacity (FVC)
naturally decreases with age; however, an excessive decline may be related with increased …