Sphingolipids represent a class of diverse bioactive lipid molecules that are increasingly
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …

Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora
of functions from the formation of structural domains to polarized cellular trafficking and …

Ceramide, an intracellular lipid mediator, is generated by transient hydrolysis of
sphingomyelin in response to agonists inducing inflammation and apoptosis, ionizing …

Pharmacological interference with sphingolipid metabolizing enzymes promises to provide
novel ways to modulate cellular pathways relevant in multiple diseases. In this review, we …

Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …

Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and
sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An …

Increasingly recognized as bioactive molecules, sphingolipids have been studied in a
variety of disease models. The impact of sphingolipids on cancer research facilitated the …

Sphingolipids are an important class of lipid molecules that play fundamental roles in our
cells and body. Beyond a structural role, it is now clearly established that sphingolipids …

Sphingolipids are both structural molecules that are essential for cell architecture and
second messengers that are involved in numerous cell functions. Ceramide is the central …

Sphingomyelin constitutes membrane microdomains such as lipid raft, caveolae, and
clathrin-coated pits and implicates in the regulation of trans-membrane signaling. On the …