Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases
D Canals, DM Perry, RW Jenkins… - British journal of …, 2011 - Wiley Online Library
Sphingolipids represent a class of diverse bioactive lipid molecules that are increasingly
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …
appreciated as key modulators of diverse physiologic and pathophysiologic processes that …
Sphingolipid and ceramide homeostasis: potential therapeutic targets
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora
of functions from the formation of structural domains to polarized cellular trafficking and …
of functions from the formation of structural domains to polarized cellular trafficking and …
Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate
RA Claus, MJ Dorer, AC Bunck… - Current medicinal …, 2009 - ingentaconnect.com
Ceramide, an intracellular lipid mediator, is generated by transient hydrolysis of
sphingomyelin in response to agonists inducing inflammation and apoptosis, ionizing …
sphingomyelin in response to agonists inducing inflammation and apoptosis, ionizing …
Sphingolipid metabolizing enzymes as novel therapeutic targets
A Billich, T Baumruker - Lipids in Health and Disease, 2008 - Springer
Pharmacological interference with sphingolipid metabolizing enzymes promises to provide
novel ways to modulate cellular pathways relevant in multiple diseases. In this review, we …
novel ways to modulate cellular pathways relevant in multiple diseases. In this review, we …
Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases
Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …
Small molecule inhibitors of acid sphingomyelinase
C Arenz - Cellular Physiology and Biochemistry, 2010 - karger.com
Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and
sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An …
sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An …
Molecular targeting of acid ceramidase: implications to cancer therapy
YH Zeidan, RW Jenkins, JB Korman, X Liu… - Current drug …, 2008 - ingentaconnect.com
Increasingly recognized as bioactive molecules, sphingolipids have been studied in a
variety of disease models. The impact of sphingolipids on cancer research facilitated the …
variety of disease models. The impact of sphingolipids on cancer research facilitated the …
Sphingolipid metabolism and neutral sphingomyelinases
Sphingolipids are an important class of lipid molecules that play fundamental roles in our
cells and body. Beyond a structural role, it is now clearly established that sphingolipids …
cells and body. Beyond a structural role, it is now clearly established that sphingolipids …
Ceramide metabolism enzymes—Therapeutic targets against cancer
A Gomez-Larrauri, U Das Adhikari, M Aramburu-Nuñez… - Medicina, 2021 - mdpi.com
Sphingolipids are both structural molecules that are essential for cell architecture and
second messengers that are involved in numerous cell functions. Ceramide is the central …
second messengers that are involved in numerous cell functions. Ceramide is the central …
The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration—from cell and animal models to human disorders
M Taniguchi, T Okazaki - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Sphingomyelin constitutes membrane microdomains such as lipid raft, caveolae, and
clathrin-coated pits and implicates in the regulation of trans-membrane signaling. On the …
clathrin-coated pits and implicates in the regulation of trans-membrane signaling. On the …